Speaker : Dr. Aleeza Gerstein – University of Manitoba – Departments of Microbiology And Statistics
Title : Parallelism and variability in the evolution of drug resistance and virulence in fungal microbes
The appearance of individual-level genotypic and phenotypic variation within a population is a requirement for adaptation. In contrast to bacterial microbes that often acquire beneficial alleles through horizontal transmission, fungal microbes adapt through vertical transmission of genomic mutations (e.g., single nucleotide, insertions, deletions) and karyotypic mutations (i.e., changes in ploidy, the number of chromosome sets, and aneuploidy, copy number change in one or several chromosomes). I will describe empirical experiments that show how different factors influence the degree genotypic and phenotypic convergence in the evolution drug resistance and virulence in fungal microbes.