Speaker : Dr. Patrick Sung – Yale University – Molecular Biophysics and Biochemistry
Title : Roles of BRCA Complexes in Chromosome Damage Repair
The tumor suppressors BRCA1, BARD1, and BRCA2 help mediate the homology-directed repair (HDR) of chromosomes that harbor DNA breaks or injured DNA replication forks. BRCA1 forms a heterodimer with BARD1, and BRCA2 associates stably with the small acidic protein DSS1. The mechanistic roles that the BRCA1-BARD1 and BRCA2-DSS1 complexes fulfill in the HDR process will be discussed.