Rosa daSilva, Ph.D.

Telephone: (905) 525-9140

Office: LSB-540 Ext 26314

Lab: BSB 207

Email: rosa.dasilva@mcmaster.ca

Website: www.rosadasilvaphd.com

Research: https://thestinkbugproject.com/

Interests & Activities

My research interests in the laboratory are focused on the cellular and molecular mechanisms that underlie systemic animal physiology, developmental biology, and both human and comparative anatomy and physiology.  In particular, I am interested in the molecular and cellular biology of cell-cell interactions, motility, and proliferation, with emphasis on how interrupted protein-protein interactions can lead to aberrant cellular activity such as tumorigenesis and cancer.

I focus the emphasis of my pedagogical research on re-engaging students back into the classroom through the use of social media and emerging technologies.  Through these means, my specific interests lie in connecting students with topics discussed within my classrooms using real-time scientific discoveries to develop student scientific literacy in the digital age.

Publications
  • Defferrari MS, da Silva R, Orchard I & CR Carlini. (2014) Jack bean (Canavalia ensiformis) urease induces eicosanoid-modulated hemocyte aggregation in the Chagas’ disease vector Rhodnius prolixus. Toxicon. 82:18-25.
  • Pustylnik S, Fiorino C, Nabavi N, Zappitelli T, da Silva R & RE Harrison. (2013) EB1 levels are elevated in ascorbic acid (AA)-stimulated osteoblasts and mediate cell-cell adhesion induced osteoblast differentiation. J Biol Chem. 288(30):22096-110.
  • Bhatt G, da Silva R, Nachman R & I Orchard. In Press. The molecular characterization of the kinin transcript and the physiological effects of kinins in the blood-gorging insect Rhodnius prolixus. Peptides. DOI: http://dx.doi.org/10.1016/j.peptides.2013.04.009,
  • Lee D, Taufique H, da Silva R & AB Lange. (2012) An unusual myosuppressin from the blood-feeding bug Rhodnius prolixus. J Exp Biol. 215(Pt 12):2088-95.
  • da Silva R, da Silva SR & AB Lange. (2012) The regulation of cardiac activity by nitric oxide (NO) in the Vietnamese stick insect, Baculum extradentatum. Cell Signal. 24(6):1344-50.
  • da Silva R & AB Lange. (2011) Evidence of a central pattern generator regulating spermathecal muscle activity in Locusta migratoria and its coordination with oviposition. J Exp Biol. 214: 757-763.
  • da Silva S, da Silva R & AB Lange. (2011) Effects of crustacean cardioactive peptide on the hearts of two Orthopteran insects, and the demonstration of a Frank-Starling-like effect. Gen Comp Endocrinol. 171(2):218-24.
  • Orchard I, Lee do H, da Silva R, Lange AB. (2011) The proctolin gene and biological effects of proctolin in the blood-feeding bug, Rhodnius prolixus. Front Endocrinol (Lausanne). 2:59.
  • Lange AB, Calvin A & R da Silva R. (2009) Neuropeptides modulate the heart of the stick insect Baculum extradentatum. Ann NY Acad Sci. 1163:448-50.
  • da Silva R & AB Lange. (2008) Tyramine as a possible neurotransmitter/neuromodulator at the spermatheca of the African migratory locust, Locusta migratoria. J Insect Physiol. 54(8):1306-13.
  • Lange AB & R da Silva. (2007) Neural and hormonal control of muscular activity of the spermatheca in the locust, Locusta migratoria. Peptides. 28(1):174-84.
  • Lange, AB & R da Silva. (2007) Peptidergic innervation of the excurrent ostia of two Orthopteroid insects. Pestycydy. (3-4):11-16.
  • da Silva R & AB Lange. (2006) The association of crustacean cardioactive peptide with the spermatheca of the African migratory locust, Locusta migratoria. J Insect Physiol. 52(4):399-409.

Books: da Silva, R. (2008) The Ten Most Uncontrollable Functions of the Body. Scholastic Canada. ISBN#: 9781554483310

Research

My primary research interests deal with the cellular and molecular mechanisms that regulate various systemic processes within model organisms.  Much of this research has included work on insect model organisms to better understand digestive, renal, cardiac, neural and reproductive processes.  In particular, I have identified various regulating proteins and signalling cascades that control the cellular machinery and are vital to maximize overall systemic physiology.  In previous research, I have also investigated the role of microtubule associated proteins in the differentiation of osteoblasts during bone development, as well as examining the role of various scaffolding proteins in the process of cancer cell metastasis in an osteosarcoma bone cancer model.