Kimberly Dej, Ph.D.

Telephone: (905) 525-9140

Office: LSB-425 Ext 23125

Lab: LSB-504

Email: dejkim@mcmaster.ca

Interests & Activities

My research interests in the lab centre upon the regulatory pathways that orchestrate chromosome behaviours vital to the proper partitioning of genetic material during cell division. Research projects only open to undergraduate students.
Research interests in education focus upon the preconceptions and misconceptions that bias scientific understanding and the use of concept inventories to measure them.

Publications
  • Lee, J.Y., K.J. Dej, J.M. Lopez, and T.L. Orr-Weaver. Control of centromere localization in the MEI-S332 cohesin protection protein. Curr Biol 14(14)1277-1283.
  • Dej, K.J., C. Ahn and T.L. Orr-Weaver. 2004. Mutations in the Drosophila condensing dCAP-G: defining the role for chromosome condensation in mitosis and gene expression in interphase. Genetics 16(2): 895-906.
  • Royzman, I., A. Hayashi-Hagihara, K.J. Dej, G. Bosco, J.Y.Lee and T.L.Orr-Weaver. 2002. The E2F cell cycle regulator is required for Drosophila nurse cell DNA replication and apoptosis. Mech Dev. 119(2):225-237.
  • Gunawardane, R.N., O.C. Martin, K. Cao, L. Zhang, K. Dej, A. Iwamatsu and Y. Zheng. 2000. Characterization and reconstitution of Drosophila gamma-tubulin ring complex subunits. J Cell Biol 151(7):1513-1524.
  • Dej, K.J. and T.L. Orr-Weaver. 2000. Separation anxiety at the centromere. Trends Cell Biol 10(9):392-399.
  • Dej, K.J. and A.C. Spradling. 1999. The endocycle controls nurse cell polytene chromosome structure during Drosophila oogenesis. Development 126(2): 293-303.
  • Dej, K.J., T. Gerasimova, V. Corces and J. Boeke. 1998. A hotspot for the Drosophila gypsy retroelement in the ovo locus. NAR 26(17): 4019-4024.
Research

Research projects only open to undergraduate students for 4FO6, 4CO9 and other thesis projects.
My research interests are closely tied to my teaching practices, particularly directing honours undergraduate research projects. To date these interests have centered on the regulatory pathways that orchestrate chromosome behaviours vital to the proper partitioning of genetic material during cell division. A failure to proportion genetic material equally to each daughter cell leads to cells with incorrect genome complements (aneuploidy), a situation associated with tumorigenesis and birth defects. In previous work I have studied mutations that disrupt the separation of replicated sister chromatids at the metaphase to anaphase transition in mitosis during embryogenesis in Drosophila melanogaster. I expanded this research to examine the role of these genes in meiosis by identifying female sterile alleles of each gene. An aspect of my research has focused on the process of chromosome condensation and the role of the condensin complex in mitosis and meiosis using a large collection of mutations in the dcap-g gene, which codes for a condensin subunit.
Please note:  My role does not involve supervision of graduate students.