John A. Hassell, Ph.D.
Telephone: (905) 525-9140
Office: MDCL 5028 Ext 27217
Lab: MDCL 5071 Ext Ext 27218
The role and mechanism of action of proto-oncogene products in cancer and development.
- Howe, L.R. Crawford, H.C., Subbaramaiah, K., Hassell, J.A., Dannenberg, A.J. and Brown, A.M.C. (2001). PEA3 is upregulated in response to Wnt-1 and activates the expression of cyclooxegenase-2. J. Biol. Chem. (in press).
- Bojovic, B. and J. A. Hassell (2001). The PEAS Ets transcription factor comprises multiple domains that regulate transactivation and DNA binding.J. Biol. Chem. 276: 4509-4521.
- Crawford, H.C., Hassell, J.A. and Matrisian, L.M. (2001). β-catenin and the PEAS subfamily of Ets transcription factors synergistically activate matrilysin transcription. Mol. Cell. Biol. 21: 1370-1383.
- Amanatullah, D.F., B.T. Zafonte, C. Albanese, M. Fu, C. Messier, J. Hassell and R.G. Pestell. (2001). Ras Regulation of the Cyclin Dl Promoter. Methods in Enzymology. 333: 116-127.
- Shepherd, T. and J.A. Hassell. (2001). Role of Ets transcription factors in mammary gland development and oncogenesis. J. Mam. Gland Biol. and Neoplasia 6: 129-140.
- Laing, M.A., Coonrod, S., Hinton, B.T., Downie, J.W. Tozer, R., Rudnicki, M.A. and J.A. Hassell (2000). Male sexual dysfunction in mice bearing targeted mutant alleles of the PEAS ets gene. Mol. Cell. Biol. 20: 9337-9345.
- O’Hagan, R.C. and J.A. Hassell. The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase. Oncogene16: 301-310 (1998).
- Taylor, J.M., Dupont-Versteegden, E.E., Davies, J.D., Hassell, J.A., Houlé, Gurley, C.M. and Peterson, C.A. A role for the Ets domain transcription factor PEA3 in myogenic differentiation. Mol. Cell. Biol. 17: 5550-5558 (1997).
- Benz, C.C., R.C. O’Hagan, B. Richter, G. K. Scott, C.-H. Chang, X. Xiong, K. Chew, B.-M. Ljung, S. Edgerton, A. Thor, and J. A. Hassell (1997). HER2/Neu and the Ets transcription factor PEA3 are coordinately upregulated in human breast cancer. Oncogene 15: 1513-1526 (1997).
- O’Hagan, R., M. Symons, F. McCormick, and J. A. Hassell. The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades. Oncogene 13: 1323-1333 (1996).
- Trimble, M.S., J.-H. Xin, C.T. Guy, W.J. Muller, and J.A. Hassell. PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas.Oncogene 8: 3037-3042 (1993).
The mammalian ETS gene family comprises over 30 members that have been grouped into subfamilies based on the relatedness of their sequence. The products of these genes are sequence specific transcription factors. The overexpression and mutation of ETS genes have been associated with multiple human malignancies. Our research program is centered on elucidating the structure-function and regulation of the expression and activity of the PEAS subfamily of Ets proteins, and uncovering their role in mammary gland development and the genesis and progression of breast cancer. The PEAS subfamily comprises PEAS, ER81 and ERM; these three genes are overexpressed in breast cancer and are thought to play key regulatory roles in the genesis and progression of this disease.