Colin B. Seymour, Ph.D.

Telephone: (905) 525-9140

Office: NRB 231 Ext 26289

Email: seymouc@mcmaster.ca

Interests & Activities

Colin’s research interests involve the understanding of the risks of very low doses of ionizing radiation to humans and the environment, with particular emphasis on the mechanisms of low-dose effects. Identification of early events and the mechanisms involved in radiation carcinogenesis are also examined. Study of the mechanisms involved in genomic instability, and their relevance to the repair of radiation damage and radiation-induced carcinogenesis. Development of bio-indicators of radiation stress in non-human species after low doses of alpha, beta, and gamma radioisotopes involve in uranium, radium, and tritium decay.

Publications

1. Induction of bystander response in human glioma cells using high-energy electrons: a role for TGF-beta1.

Gow MD. Seymour CB. Ryan LA. Mothersill CE.

Radiation Research. 173(6):769-78, 2010 Jun.

2. Eco-systems biology–from the gene to the stream.

Mothersill C. Seymour C.

Mutation Research. 687(1-2):63-6, 2010 May 1.

3. Investigation of non-linear adaptive responses and split dose recovery induced by ionizing radiation in three human epithelial derived cell lines.

Ryan LA. Seymour CB. Mothersill CE.

Dose-response: A Publication of International Hormesis Society. 7(4):292-306, 2009.

4. Communication of ionising radiation signals–a tale of two fish.

Mothersill C. Seymour C.

International Journal of Radiation Biology. 85(11):909-19, 2009 Nov.

5. Communication of radiation-induced signals in vivo between DNA repair deficient and proficient medaka (Oryzias latipes).

Mothersill C. Smith RW. Hinton TG. Aizawa K. Seymour CB.

Environmental Science & Technology. 43(9):3335-42, 2009 May 1.

6. Implications for environmental health of multiple stressors.

Mothersill C. Seymour C.

Journal of Radiological Protection. 29(2A):A21-8, 2009 Jun.

7. Development of a zebrafish spleen cell line, ZSSJ, and its growth arrest by gamma irradiation and capacity to act as feeder cells.

Xing JG. El-Sweisi W. Lee LE. Collodi P. Seymour C. Mothersill C. Bols NC.

In Vitro Cellular & Developmental Biology. Animal. 45(3-4):163-74, 2009 Mar-Apr.

8. Radiation-induced adaptive response is not seen in cell lines showing a bystander effect but is seen in lines showing HRS/IRR response.

Ryan LA. Seymour CB. Joiner MC. Mothersill CE.

International Journal of Radiation Biology. 85(1):87-95, 2009 Jan.

9. Bystander effect induced changes in apoptosis related proteins and terminal differentiation in in vitro murine bladder cultures.

Vines AM. Lyng FM. McClean B. Seymour C. Mothersill CE.

International Journal of Radiation Biology. 85(1):48-56, 2009 Jan.

10. Environmentally relevant mixed exposures to radiation and heavy metals induce measurable stress responses in Atlantic salmon.

Salbu B. Denbeigh J. Smith RW. Heier LS. Teien HC. Rosseland BO. Oughton D. Seymour CB. Mothersill C.

Environmental Science & Technology. 42(9):3441-6, 2008 May 1.

Research