• Genetics & Molecular Biology

    Genetics & Molecular Biology

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All courses for every first-year Science student will be delivered online this fall. A limited number of students in their second, third and fourth years will return to campus for part of the semester.

Molecular Biology is a fundamental area of investigative research in Biology that employs new technologies and experimental approaches to examine fundamental processes in all living organisms. In the course of these investigations, we use wide variety of model organisms, including mice, guinea pigs, human tissue cell cultures, the nematode species Caenorhabditis elegans, the plant Arabidopsis thaliana, model bacteria and the fruit fly Drosophila melanogaster. The research is of immediate relevance to human health in many areas including cancer, inherited genetic diseases and disease resistance, DNA repair, and neurosystem development and function. We welcome strong applicants as undergraduate researchers, graduate students and postdoctoral fellows.

Andre Bedard
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Professor
LSB 430
(905) 525-9140 ext. 23149
...

Research in my laboratory is centered on the study of cell proliferation and cell transformation. The control of gene expression in quiescent primary chicken embryo fibroblasts (CEF) is the focus of our current research program. In particular, we recently uncovered a novel response to the conditions of limited oxygen concentrations experienced by contact inhibited CEF and showed that this response is critical for the maintenance of lipid/membrane homeostasis and cell survival. Current investigations have for objective to characterize the cellular processes regulated by the lipid/membrane damage response promoting reversible growth arrest and survival of quiescent cells. To do this work we employ basic techniques of cell and molecular biology as well as genomic, proteomic and lipidomic approaches.

Cell and Developmental Biology; Genetics & Molecular Biology

  • Maslikowski, B.M., Wang, L., Wu, Y., Fielding, B. and Bédard, P.-A. (2017). JunD/AP-1 antagonizes the induction of DAPK1 to promote the survival of v-Src transformed cells. J. Virol. 91(1): e01925-16.
  • Erb. M., Camacho, D., Xie, W., Maslikowski, B.M., Fielding, B., Ghosh, R., Poujade, F.-A., Athar, M., Assee, S., Mantella, L.-E., and Bédard, P.-A. (2016). Mol. Cell. Biol. 36: 2890-2902.
  • Bassey-Archibong, B.I., kwiecien, J.M., Milosavljevic, S.B., Hallett, R.M., Rayner, L.G., Erb, M.J., Crawford-Brown, C.J., Stephenson, K.B., Bédard, P.-A., Hassell, J.A., and Daniel, J.M. (2016). Kaiso depletion attenuates transforming growth factor-b signaling and metastatic activity of triple-negative breast cancer cells. Oncogenesis 5:e208.
  • Klionsky et al, (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222.
  • Maynard, S., Ghosh, R., Wu, Y., Yan, S., Miyake, T., Gagliardi, M., Rethoret, K. and Bédard, P.-A. (2015). GABARAP is a determinant of apoptosis in growth-arrested chicken embryo fibroblasts. J. Cell. Physiol. 230: 1475-1488.
  • Wang, L., Rodrigues, N.A., Wu, Y., Maslikowski, B., Singh, N., Lacroix, S. and Bédard, P.-A. (2011). Pleiotropic action of AP-1 in v-Src transformed cells. J. Virol. 85:6725-6735.
  • Maslikowski, B., Néel, B.D., Wu, Y., Wang. L., Rodrigues, N.A., Gillet, G. and Bédard, P.-A. (2010).  Cellular processes of v-Src transformation revealed by gene profiling of primary cells – Implications for human cancer. BMC Cancer 10:41
  • Papaconstantinou, M., Pepper, A.N., Wu, Y., Kasimer, D., Westwood, T., Campos, A.R. and Bédard, P.-A. (2010). Menin links the stress response to genome stability.  PLoS One 5:e14049.
  • Papaconstantinou, M, Maslikowski, B., Pepper, A.N. and Bédard, P.-A. (2009).  Menin, the protein behind the MEN1 syndrome.  Adv. Experim. Med. Bio, 668:26-36 (review).
  • Grondin, B., Lefrançois, M., Tremblay, M., Saint-Denis, M., Haman, A.,Bédard, P.-A., Tenen, D.G., and Hoang, T. 2007. c-Jun homodimers can function as a context-specific coactivator. Mol. Cell. Biol. 27: 2919-2933
  • Campos, C.B.L., Bédard, P.-A. and Linden, R. (2006).  Requirement of p38 stress-activated MAP kinase for cell death in the developing retina depends on the stage of cell differentiation. Neurochem. Int. 49:494-499
  • Papaconstantinou, M., Wu, Y., Singh, N., Gianfelice,G., Tanguay, R.M., Campos, A.R. and P.-A. Bédard.  (2005).  Menin is a regulator of the stress response in Drosophila melanogaster. Mol. Cell. Biol. 25: 9960-9972
  • Campos, C.B., P.-A. Bédard and R. Linden. (2003). Selective involvement of the PI3K/PKB/bad pathway in retinal cell death. J. Neurobiol. 56: 171-177.
  • Gagliardi, M., Maynard, S., Miyake T., Rodrigues N., Tjew S.-L., Cabannes E. and P.-A.  Bédard. (2003). Opposing roles of C/EBPb and AP-1 in the control of fibroblast proliferation and growth-arrest specific gene expression. J. Biol. Chem. 278: 43846-43854.
  • Campos, CB, Bédard, P.-A. and Linden, R. Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina . Neuroscience 112: 583-591 (2002).
  • Gagliardi, M., Maynard, S., Bojovic, B. and Bédard, P.-A. The constitutive activation of the CEF-4/9E3 chemokine gene depends on C/EBPb in v-src transformed chicken embryo fibroblasts. Oncogene 20: 2301-2313 (2001).
  • Kim, S., Mao, P.L., Gagliardi, M. and Bédard, P.-A. C/EBPb (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. Mol Cell. Biol. 19: 5718-5731 (1999).
  • Cabannes, E., Vives, M.-F. and Bédard, P.-A. (1997). Transcriptional and post-transcriptional regulation of KappaB-controlled genes by pp60v-src.Oncogene 15: 29-43(1997).
  • Bojovic, B., Rodrigues, N., Dehbi, M. and Bédard, P.-A. Multiple signaling pathways control the activation of the CEF-4/9E3 cytokine gene by pp60v-src.J. Biol. Chem. 271: 22528-22537 (1996).
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