Research in my laboratory is centered on the study of cell proliferation and cell transformation. The control of gene expression in quiescent primary chicken embryo fibroblasts (CEF) is the focus of our current research program. In particular, we recently uncovered a novel response to the conditions of limited oxygen concentrations experienced by contact inhibited CEF and showed that this response is critical for the maintenance of lipid/membrane homeostasis and cell survival. Current investigations have for objective to characterize the cellular processes regulated by the lipid/membrane damage response promoting reversible growth arrest and survival of quiescent cells. To do this work we employ basic techniques of cell and molecular biology as well as genomic, proteomic and lipidomic approaches.
Cell and Developmental Biology; Genetics & Molecular Biology