Ana Campos
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Associate Member, Director, School of Interdisciplinary Studies
LSB 541
(905) 525-9140 ext. 23095

The ability to generate genetic variants has greatly aided the study of biochemical and developmental pathways. Given the success of this approach it is not surprising that genetics is being used to address a wide range of neurobiological questions including the generation of behaviour. My laboratory uses the larval visual system of the fruit fly Drosophila melanogaster as a model system to investigate the mechanisms underlying the development and function of the nervous system. To that end, mutations or molecular tools are used to impair specific cell types and/or cellular interactions. Mutations found to disrupt the development of the larval visual system or the larval response to light can be used to identify molecules involved in these processes. Thus, my research programme can be divided in two parts namely the genetic analysis of the larval response to light and the molecular genetic analysis of genes required for the development of the larval visual system. To address these questions a variety of techniques are used such as mutant analysis, molecular and cell biology.

Cell and Developmental Biology; Genetics & Molecular Biology

  • Zhao XL, Campos AR. (2012) Insulin signaling in mushroom body neurons regulates feeding behaviour in Drosophila larvae. J. Exp. Biol. 215:2696-702.
  • Papaconstantinou, M, Pepper, AN, Wu, Y, Kasimer, D, Westwood, T, Campos, AR, Bédard, P-A. (2010). Menin links the stress response to genome stability. PLoS One 5:e14049.
  • Scantlebury N, Zhao XL, Rodriguez Moncalvo VG, Camiletti A, Zahanova S, Dineen A, Xin JH, Campos AR. (2010) The Drosophila gene RanBPM functions in the mushroom body to regulate larval behaviour. PLoS One 5:e10652.
  • Rodriguez Moncalvo VG, Campos AR. (2009) Role of serotonergic neurons in the Drosophila larval response to light. BMC Neurosci. 10:66.
  • Scantlebury N, Sajic R, Campos AR. (2007) Kinematic analysis of Drosophila larval locomotion in response to intermittent light pulses. Behav. Genet. 37:513-24.
  • Papaconstantinou, M, Wu, Y, Singh, N, Gianfelice, G, Tanguay, RM, Campos, AR, Bédard, P-A. (2005). Menin is a regulator of the stress response in Drosophila melanogaster. Mol. Cell. Biol. 25:9960-72.
  • Rodriguez Moncalvo VG, Campos AR. (2005) Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev. Biol. 286:549-58.
  • Hassan J, Iyengar B, Scantlebury N, Rodriguez Moncalvo V, Campos AR. (2005) Photic input pathways that mediate the Drosophila larval response to light and circadian rhythmicity are developmentally related but functionally distinct. J. Comp. Neurol. 481:266-75.
  • DeSousa D, Mukhopadhyay M, Pelka P, Zhao X, Dey BK, Robert V, Pélisson A, Bucheton A, Campos AR. (2003) A novel double-stranded RNA binding protein, disco interacting protein 1 (DIP1), contributes to cell fate decisions during Drosophila development. J. Biol. Chem. 278:38040-50.
  • Iyengar B, Luo N, Farr CL, Kaguni LS, Campos AR. (2002) The accessory subunit of DNA polymerase gamma is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 99:4483-88.
  • Hassan, J, Busto, M., lyengar, B. and Campos A. R. 2000. Behavioral characterization and genetic analysis of the Drosophila melanogaster response to light as revealed by a novel individual assay. Behavior. Genetics, 30: 59-69.
  • Busto, M., lyengar, B. and A. R. Campos. 1999. Genetic dissection of behavior: Modulation of locomotion by light in the Drosophila melanogaster larva requires genetically distinct visual system functions. J Neuroscience19: 3337-3344.
  • Lee, K.J., Mukhopadhyay, M., Pelka, P., Campos, A.R. and H. Steller 1999. Autoregulation of the Drosophila disconnected gene in the developing visual system. Dev. Biol, 214:385-398.
  • lyengar, B., Roote, J. and A. R. Campos. 1999. The tamas gene identifed as a mutation that disrupts larval behavior codes for the mitochondrial DNA polymerase catalytic subunit (DNApol-γl25). Genetics, 153: 1809-1824.
  • Mukhopadhyay, M. and A.R. Campos. The larval optic nerve is required for the development of an identified serotonergic arborization in Drosophila melanogaster. Dev. Biol. 169: 629-643 (1995).
  • Campos, A.R., K.J. Lee and H. Steller. Establishment of neuronal connectivity during the development of the Drosophila larval visual system.J. Neurobiology, 28: 313-329 (1995).
  • Sawin, E.P., L.R. Harris, A.R. Campos and M.B. Sokolowski. Sensorimotor transformation from light reception to phototactic behavior in Drosophila larvae. (Diptera: Drosophilidae). J. Insect. Behav. 7: 553-567 (1994).
  • Sawin-McCormack, E., M.B. Sokolowski and A.R. Campos.Characterization and genetic analysis of Drosophila melanogaster photobehaviour during larval development. J. Neurogenetics 10: 119-135 (1995).
  • Campos, A.R., Fishbach and H.S. Steller. Survival of the photoreceptor neurons in the compound eye of Drosophila depends on connections with the optic ganglia. Development 114: 355-366 (1992).
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McMaster University - Faculty of Science | Biology