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Latest information and updates about COVID-19 from McMaster University:   Course Outlines & Plans COVID-19 Website

Latest information and updates about COVID-19 from McMaster University:

Roger Jacobs
Profile Photo
Professor
LSB 429
(905) 525-9140 ext. 27350
...

The heart is the organ most often affected by congenital malformations, as well as diseases associated with aging. Uncovering the molecular and genetic mechanisms that underlie these problems can be accelerated through study with simpler genetic models such as the fruitfly, Drosophila. The Jacobs lab employs the Drosophila genetic model to dissect heart formation and growth of the heart, with particular focus on adhesion signaling, cell polarity, morphogenesis and the formation and remodeling of the heart extra-cellular matrix.

Cell and Developmental Biology; Genetics & Molecular Biology

  • Ghaemi R, Arefi P, Stosic A, Acker M, Raza Q, Jacobs JR and Selvaganapathy PR. (2017) A microfluidic microinjector for toxicological and developmental studies in Drosophila embryos. Lab Chip, 2017, http://dx.doi.org/10.1039/C7LC00537G
  • Hughes, CJR and Jacobs, JR (2017) Dissecting the Role of the Extracellular Matrix in Heart Disease: Lessons from the Drosophila Genetic Model. Vet. Sci. 2017, 4, 24; doi:10.3390/vetsci4020024
  • Vanderploeg J, Jacobs JR (2017) Mapping heart development in flies: Src42A acts non-autonomously to promote heart tube formation in Drosophila. Vet. Sci. 2017, 4, 23; doi:10.3390/vetsci4020023
  • Raza Q, Vanderploeg, J Jacobs JR. (2017) Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development. PlosONE PLoS Feb 13;12(2):e0171905. http://dx.doi.org/10.1371/journal.pone.0171905
  • Raza Q, Jacobs JR (2016) Guidance signalling regulates leading edge behaviour during collective cell migration of cardiac cells in Drosophila. Dev Biol. 419(2):285-297 http://dx.doi.org/10.1016/j.ydbio.2016.09.005
  • Bogatan S, Cevik D, Demidov V, Vanderploeg J, Panchbhaya A, Vitkin A, Jacobs JR.(2015) Talin Is Required Continuously for Cardiomyocyte Remodeling during Heart Growth in Drosophila. PLoS One. 2015 Jun 25;10(6)pub icon
  • Vanderploeg J, Jacobs JR.(2015) Talin is required to position and expand the luminal domain of the Drosophila heart tube. Dev Biol. 2015 Sep 15;405(2):189-201. pub icon
  • Vanderploeg J, Vazquez Paz LL, MacMullin A, Jacobs JR. (2012) Integrins are required for cardioblast polarisation in Drosophila. BMC Dev Biol. 12:8. pub icon
  • Knox J, Moyer K, Yacoub N, Soldaat C, Komosa M, Vassilieva K, Wilk R, Hu J,Vazquez Paz Lde L, Syed Q, Krause HM, Georgescu M, Jacobs JR.  (2011) Syndecan contributes to heart cell specification and lumen formation during Drosophila cardiogenesis. Dev Biol. 356:279-90. pub icon
  • Moyer KE, Jacobs, JR. (2008) Varicose: a MAGUK required for the maturation and function of Drosophila septate junctions. BMC Dev Biol. 8:99  pub icon
  • MacMullin A and Jacobs, JR. (2006) Slit coordinates cardiac morphogenesis in Drosophila. Dev Biol. 293:154-64. 
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  • Settle, M., Gordon, M.D., Nadella, M., Dankort, D., Muller, W., Jacobs, J.R. (2003) Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.Oncogene 22:1916-1926. 
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  • Stevens, A. and Jacobs, J.R. (2002) Integrins Regulate Responsiveness to Slit Repellent Signals J. Neurosci. 22: 4448-4455. pub icon
  • Battye, R.A., Stevens, A., Perry, R., and Jacobs, J.R. (2001) Repellent signaling from Slit requires the Leucine Rich Region. J. Neurosci . 21:4290-4298 
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  • Jacobs, J.R. (2000) The Midline Glia of Drosophila: A molecular genetic model for the developmental functions of glia. Prog. Neurobiol. 62:475-508  pub icon
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