Sajeni Mahalingam
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Undergraduate Coordinator level 1 courses - on leave
BSB 201A/B
(905) 525-9140 ext. 26369
...

Primary focus of my research has been the molecular regulation of intracellular transport, with emphasis on lipid metabolism along trafficking pathways. My studies into the role of membrane remodeling in endocytic recycling processes aimed to dissect molecular mechanism of membrane tubulation within the recycling compartment, demonstrating its role in efficient recycling of receptors such as integrins during metastasis. I am particularly interested in lipid fluxes in living cells that can be monitored through the development and optimization of high-resolution imaging approaches and probes. I used these approaches to determine individual roles of specific lipids in processes ranging from vesicular fusion to sphingolipid homeostasis and lysosomal storage diseases. I have applied my expertise in membrane biology and trafficking to develop a new line of investigation of endocrine signaling with my collaborators at the National Institutes of Health.

As a STEM educator, I am passionate about personalized, life-long science education that is competency-based and research-intensive. Through collaborations, outreach and advocacy, my pedagogical work explores the potential for an immersive, digital environment in mastering abstract scientific concepts.

Sengupta N, Jović M, Barnaeva E, Kim DW, Hu X, Southall N, Dejmek M, Mejdrova I, Nencka R, Baumlova A, Chalupska D, Boura E, Ferrer M, Marugan J, Balla T. A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha. J Lipid Res. 2019 60(3):683-693.

Jović M Online Competency-Based Biochemistry Education in an Online Format - Interactive and Quantifiable FASEB Journal 2016 30 (1) 194.

Jeschke A, Zehethofer N, Lindner B, Krupp J, Schwudke D, Haneburger I, Jović M, Backer JM, Balla T, Hilbi H, Haas A. Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. Proc Natl Acad Sci U S A. 2015, 112(15):4636-41.

Bojjireddy N, Guzman-Hernandez ML, Reinhard NR, Jović M, Balla T. EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors. J Cell Sci. 2015 1;128(1):118-28.

Jović M ¶, Kean MJ, Dubankova A, Boura E, Gingras AC, Brill JA, Balla T. Endosomal sorting of VAMP3 is regulated by PI4K2A. J Cell Sci. 2014, 1;127:3745-56

Baumlova A, Chalupska D, Róźycki B, Jović M, Wisniewski E, Klima M, Dubankova A, Kloer DP, Nencka R, Balla T, Boura E. The crystal structure of the phosphatidylinositol 4-kinase IIα. EMBO Rep. 2014, 15(10):1085-92.

Salcedo-Sicilia L, Granell S, Jović M, Sicart A, Mato E, Johannes L, Balla T, Egea G. βIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex. J Biol Chem. 2013, 25: 2157-66.

Cruz-Garcia D, Ortega-Bellido M, Scarpa M, Villeneuve J, Jović M, Porzner M, Balla T, Seufferlein T, Malhotra V. Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export. EMBO J. 2013, 12;32(12):1717-29.

Jović M, Kean MJ, Szentpetery Z, Polevoy G, Gingras AC, Brill JA, Balla T. Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase Mol Biol Cell. 2012, 23:1533-45.

Jović M*, Sharma M*, Rahajeng J, Caplan S. The early endosome: a busy sorting station for proteins at the crossroads. Histol Histopathol. 2010, 25: 99-112.

Jović M*, Kieken F*, Sharma M*, Giridharan SS, Naslavsky N, Caplan S, Sorgen PL. Mechanism for the selective interaction of C-terminal EH-domain proteins with specific NPF-containing partners. J Biol. Chem. 2010,19:8687-94

Jović M, Kieken F, Naslavsky N, Sorgen P, Caplan S. EHD1-associated tubules contain phosphatidylinositol-4-phosphate and phosphatidylinositol-(4,5)-bisphosphate and are required for efficient recycling. Mol. Biol. Cell 2009, 20:2731-43.

Jović M, Naslavsky N, Rapaport D, Horowitz M, Caplan S. EHD1 regulates β1 integrin endosomal transport: effects on focal adhesions, cell spreading and migration. J Cell Sci. 2007, 120:802-814. *Highlighted in the Nature Cell Migration Gateway

Kieken F, Jović M, Tonelli M, Naslavsky N, Caplan S, Sorgen P. Structural insight into the interaction of proteins containing NPF, DPF, AND GPF motifs with the C-terminal EH-domain of EHD1. Protein Sci. 2009, 18: 2471-9.

Sharma M, Jović M, Kieken F, Naslavsky N, Sorgen P, Caplan S. A model for the role of EHD1-containing membrane tubules in endocytic recycling. Comm. and Int. Bio. 2009 2: 431-3.

Kieken F, Jović M, Caplan S, Sorgen P. NMR structure note: EH domain of EHD1. J Biomol NMR 2007,39 (4):323-9.

Jović M*, Sharma M*, Caplan S. Epidermal Growth Factor Receptor Protein Tyrosine Kinease Substrate (Eps15) Targeted Proteins Database, 2007 doi:10.2970/tpdb.2007 (peer reviewed)

Naslavsky N, Rahajeng J, Sharma M, Jović M, Caplan S. Interactions between EHD Proteins and Rab11-FIP2: A Role for EHD3 in Early Endosomal Transport. Mol. Biol. Cell 2006, 17:163–177.

Christensen D, Jović M. Mini-Array Transcriptional Analysis of the Listeria monocytogenes Lecithinase Operon as a Class Project. Bioc. and Mol. Biol. Edu. 2006, 34:221-226.

¶ corresponding author * denotes equal contribution

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McMaster University - Faculty of Science | Biology