Grant McClelland index MacMaster
 
 
Former Lab Members
Postdoctoral fellows

Dr. Amber Schlater (PhD CSU Fort Collins)
Position: PostDoc

Skeletal muscle adaptations to hypoxic and cold environments

Currently Assistant Prof. @ College of St. Scholastica, MN

Dr. Kevin Tate (PhD U North Texas)
Position: PostDoc (jointly with G. Scott)

Mechanisms and evolution of thermogenic capacity in high-altitude deer mice

Currently Assistant Prof. @ Texas Lutheran U

Tate, K.B., Wearing, O.H., Ivy, C.M., Cheviron, Z.A., Storz, J.F., McClelland, G.B., and Scott, G.R. (2020). Coordinated changes across the O2 cascade underlie adaptive increases in thermogenic capacity in high-altitude deer mice. Proc. Roy. Soc. B. 287: 20192750.

Dr. Chris Le Moine (PhD Queens U)
Position: PostDoc

Hypoxic muscle remodelling

Currently Associate Prof. @ Brandon U

Le Moine, C.M.R., Morash, A.J., and McClelland, G.B. (2011) Role of HIF-1α and pyruvate dehydrogenase phosphorylation in exercise blood lactate changes with the transition from acute to chronic hypoxia. Am. J. Physiol. 301:R1098-R1104.

Dr. Makiko Kajimura (PhD)
Position: PostDoc

Regulation of fat oxidation with environmental stress

Currently Asst. Prof. Wakayama Univ., Japan

Morash, A.J., Kajimura, M., and McClelland, G.B. (2008) Intertissue regulation of carnitine palmitoyltransferase I (CPTI): Mitochondrial membrane properties and gene expression in rainbow trout (Oncorhychus mykiss). BBA-Biomembranes 1778:1382-1389.

PhD students

Dr. Cayleih Robertson (BSc Mount Allison, MSc Guelph U)
Position: PhD

Developmental plasticity of thermogenesis in deer mice

Currently Postdoc at McMaster U

Robertson, C.E., Tattersall, G.J., and McClelland, G.B. (2019). Development of homeothermic endothermy is delayed in high altitude native deer mice (Peromyscus maniculatus Proc. R. Soc. B 286: 20190841. doi:10.1098/rspb.2019.0841286

Dr. Sajeni Mahalingam (BSc, MSc UofT)
Position: PhD (jointly with G. Scott)

Oxygen and fuel supply pathways in high altitude deer mice

Currently Undergraduate Coordinator level 1 courses, McMaster Biology

Mahalingam, S., Cheviron, Z.A., Storz, J.F., McClelland, G.B., and Scott, G.R. (2020). Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes. J. Physiol. 598(23): 5411-5426. DOI:10.1113/JP280298.

Paul Craig

Dr. Paul Craig (BSc, MSc Guelph U)
Position: PhD

The Genomic & Physiological Effects of Waterborne Copper Exposure in Zebrafish, Danio rerio

Currently Associate Prof. U Waterloo, previously NSERC PDF @ uOttawa

Craig, P.M., Wood, C.M., and McClelland, G.B. (2010) Water Chemistry alters gene expression and physiological endpoints of chronic waterborne copper exposure in zebrafish, Danio rerio. Environ. Sci. Tech. 44(6): 2156-2162

Dr. Marie-Pierre Schippers (BSc Guelph U)
Position: PhD

Muscle and exercise adaptations to high altitude in Andean mice

Currently Team Leader at Natural Sciences and Engineering Research Council of Canada (NSERC)

Schippers, M.-P., Ramirez, O., Arana, M., Bernal, P.P., and McClelland, G.B. (2012) Increase in carbohydrate utilization in high-altitude Andean mice. Current Biology. 22 (24):2350–2354.

Andrea J. Morash

Dr. Andrea Morash (BSc Mount Allison)
Position: PhD

The Evolution of Genomic and Non-Genomic Regulatory Mechanisms of Mitochondrial Lipid Oxidation in Fishes

Currently Assistant Prof Mount Allison U

Morash, A.J., Le Moine, C.M.R., and McClelland, G.B. (2010) Genome duplication events have lead to a diversification in the CPT I gene family in fish. Am. J. Physiol. 299: R579 - R589.

Masters Students

Soren Coulson (BSc McMaster U)
Position: MSc

Changes in metabolic regulation of the carbohydrate oxidative pathway in exercising high altitude deer mice

Currently PhD student Western U

Coulson, S.Z., Robertson, C.E., Mahalingam, S., and McClelland, G.B. (2021) Plasticity of non-shivering thermogenesis and brown adipose tissue in high-altitude deer mice. J. Exp. Biol., In Press..

Taylor Brooks (BSc Mount Allison U)
Position: MSc

Influence of the transition from acute to chronic hypoxia on Pyruvate Kinase 1 and lactate accumulation in C2C12 cells

Currently R&D Integricare Animal Health

Nastashya Wall (BSc Winnipeg)
Position: MSc

Cold and hypoxia acclimation in high altitude deer mice

Sheridan Baker (BSc McMaster U)
Position: MSc

Copper induced gill remodeling and chemosensing

Currently PhD student at Guelph U

Alex Connaty (BSc WLU)
Position: MSc

The effects of acute and chronic hypoxia on muscle metabolism in mice

Currently Manufacturing Supervisor, Johnson and Johnson

Cheviron, Z.A., Bachman, G.C., Connaty, A.D., McClelland, G.B., Storz, J.F. (2012) Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice. Proc. Natl. Acad. Sci., USA., 109(22):8635-40.

Victoria Ransberry (BSc Western U)
Position: MSc

Oxidative stress and metabolic responses to acute Cu exposure and hypoxia in killifish

Currently: Environmental consultant in Calgary

Ransberry, V.E., Blewett, T., and McClelland, G.B. (2016) The oxidative stress response in freshwater-adapted killifish, Fundulus heteroclitus to acute copper and hypoxia exposure. Comp Biochem Physiol C Toxicol Pharmacol. 179:11-18.

Templeman

Nicole Templeman (BSc Mt Allison; MSc McMaster)
Position: MSc

Diversity in the Regulation of Metabolic Fuel Use in Mice Selected for High Locomotor Activity

Currently Assistant Prof and Tier 2 CRC, U Victoria

Templeman, N.M., Schultz, H., Garland, T., and McClelland, G.B. (2012) Do mice selectively bred for high locomotor activity have a greater reliance on lipids to power submaximal aerobic exercise? Am. J. Physiol. 303:R101-R111.

Jacqueline Beaudry

Jacqueline Beaudry (BSc and MSc McMaster U)
Position: MSc

Conflict between cold and hypoxia acclimation

Currently Assistant Prof, U of Toronto, Nutritional Sciences

Beaudry, J.L., and McClelland, G.B. (2010) Thermogenic responses in CD-1 mice after combined chronic hypoxia and cold acclimation. Comp. Biochem. Physiol. B. 157:301-309.

Kristina Murphy (BSc Queen's, MSc McMaster)
Position: MSc

Fuel Selection in Genetically Selected Endurance Running Rats at Submaximal Exercise Intensities

Currently Personal Trainer

Marie-Pierre Schippers (BSc Guelph U, transferred to PhD)
Position: MSc (jointly with R. Dukas, PNB)

Cast and lifetime changes in muscle biochemistry in honeybees

Schippers, M.-P., Dukas, R., and McClelland, G.B. (2010) Lifetime changes in flight metabolic rate and muscle biochemistry of honeybees, Apis mellifera. J. Comp. Physiol. B. 180(1):45-55.

Undergraduate Students

Brianna Mortillaro
Position: BSc researcher

Plasticity of thermoneutral zones with cold acclimation in deer mice

Karen Sobiesiak
Position: BSc researcher

Ontogeny and plasticity of calcium handling in high altitude deer mice

Wafa Khoja
Position: BSc researcher

The liver as a hub for thermogenesis and exercise at high altitude

Katarina Djuric
Position: BSc researcher

Plasticity of brown adipose tissue to cold and hypoxia in high altitude deer mice

Srikripa Krishna Prasad
Position: BSc researcher

Skeletal muscle phenotypes for locomotion and thermogenesis

Leah Hayward
Position: BSc researcher

Changes in thermal conductance with cold acclimation in deer mice

Leanne Zubowski
Position: BSc researcher

Ontogeny of skeletal muscle fiber-type in high and low altitude deer mice

Vicky Lai
Position: BSc researcher

Ontogeny of brown adipose tissue of high and low altitude deer mice

Soren Coulson
Position: BSc researcher

Mitochondrial metabolism of brown adipose tissue from low and high-altitude deer mice

Kwasi Nkansah
Position: BSc researcher

Ontogeny of shivering thermogenesis of low and high-altitude deer mice

Debbie Chan
Position: BSc researcher

The effects of cold adaptation on the developmental regulation of Sarcolipin in deer mice

Victoria Geropoulos
Position: BSc researcher

Membrane transport limitations for lipid metabolism in highland deer mice

Adam Kulesza
Position: BSc researcher

Energetics of copper exposed killifish

Kulesza, A., Leonard, E.M., and McClelland, G.B. (2020) Influence of 96h sub-lethal copper exposure on aerobic scope and recovery from exhaustive exercise in killifish (Fundulus heteroclitus). Aquatic Toxicology. 218:105373

Taylor Valee
Position: BSc researcher

Brown adipose tissue plasticity with cold and hypoxia acclimation in deer mice

Sheridan Baker (BSc McMaster)
Position: BSc Honours research

Stimulation of respiration in Cu-exposed killifish (Fundulus heteroclitus).

Currently: PhD at Guelph U

Andrea Lam (BSc McMaster)
Position: BSc Honours research

Effect of cold acclimation on locomotory metabolism in high altitude deer mice (Peromyscus maniculatus)

Narina Jabari (BSc McMaster)
Position: BSc Honours research

Oxygen-dependent gene and protein expression under copper, hypoxia and combined copper and hypoxia exposure in the common Killifish, Fundulus Heteroclitus

Daphne Lau (BSc McMaster)
Position: BSc Honours research

Effect Of Hypoxia Acclimation On The Fuel Use Patterns Of Highland Deer Mice (Peromyscus maniculatus) During Exercise

Currently: Optometrist

Hamid Mousavi (BSc McMaster)
Position: BSc Honours research

Muscle Metabolism with Exercise in High and Low Altitude Deer Mice (Peromyscus maniculatus)

Wong

Janine Wong
Position: BSc honours research (jointly with S. Balshine, PNB)

The Effects of Contamination in Hamilton Harbour on Swimming Performance and Liver Glycogen Content in Round Gobies

Currently teaching in Korea

Daniel Li
Position: BSc honours research

The effects of acute hypoxia and copper exposure on gill morphometry and gene expression in the common killifish

Currently MSc at U of T

Sharon Nadarajah
Position: BSc honours research

Muscle signalling with exercise intensity


Currently: Physician

Mark Vanderveken
Position: BSc honours research

Changes in the machinery associated with aerobic metabolism in response to exercise in trout


Currently: Lawyer

Yu

Wilson Yu
Position: BSc Honours research

Regulatory Mechanism of Fat Metabolism in Migratory Spawning Sockeye Salmon: Expression of PPARa in Red Muscle Tissue

Currently: Thermo Fisher

Morash, A.J., Le Moine, C.M.R., Yu, W., Hill, J. A., Patterson, D.A., Farrell, A.P., and McClelland, G.B. Genomic and metabolic preparation in sockeye salmon (Oncorhynchus nerka) for spawning migration. Physiol. Biochem. Zool. (In revision)

Daniel Wheeler
Position: BSc Honours research

Acclimation of mice to hypoxia: inducing the lactate paradox

Currently: Memorial Med School, NFLD

Julie Kim
Position: BSc Honours research

Exercise induced remodelling of skeletal muscle in adult zebrafish

Currently: ER Physician

Le Moine, C.M.R., Craig, P.M., Dhekney, K., Kim, J.J., and McClelland, G.B. (2010) Temporal and spatial patterns of gene expression in skeletal muscles in response to swim training in adult zebrafish (Danio rerio). J. Comp. Physiol. B. 180(1):151-60.

Mike Galus
Position: BSc Honours research

Effect of dietary iron on water-borne Cu toxicity in zebrafish

Currently: Science Advisor, Fisheries and Oceans Canada

Craig, P.M., Galus, M., Wood, C.M., and McClelland, G.B. (2009) Dietary iron alters waterborne-copper induced gene expression in softwater acclimated zebrafish (Danio rerio). Am. J. Physiol. 296:R362-R373.

Lara Janitens
Position: BSc honours research

Genetic and enzymatic changes in mitochondrial fat oxidation in muscle of sockeye salmon through the course of migration

Currently:

Kristina Arvai
Position: BSc honours research

The effects of aquatic-to-aerial transition on gill morphology and blood metabolite levels in the plainfin midshipman

Currently:

Charles Darwin

Emma Stewart
Position: BSc Honours research

Divalent metal transporter expression in Cu exposed zebrafish

Currently: teaching in Japan?

Jack Beaudry
Position: BSc Honours research

Differences in plasma and muscle lipids between high and low aerobic capacity rats

Currently: Assistant Prof U of Toronto

Kalindi Dhekney
Position: BSc Honours research

Spacial muscle remodelling in zebrafish

Currently: Medical doctor

Le Moine, C.M.R., Craig, P.M., Dhekney, K., Kim, J.J., and McClelland, G.B. (2010) Temporal and spatial patterns of gene expression in skeletal muscles in response to swim training in adult zebrafish (Danio rerio). J. Comp. Physiol. B. 180(1):151-60.

McClelland, G.B., Craig, P.M., Dhekney, K and Dipardo, S. (2006) Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). J. Physiol. (London), 577(2):739-751.

Charles Darwin

Deanne Malenfant
Position: Summer research assistant

Exercise fuel use in rats selectively bred for running capacity

Currently: Medical doctor

Kinga Smolen (U Waterloo)
Position: BSc COOP research

Changes in Honeybee muscle proteome with foraging experience

Currently: Harvard Medical School

Schippers, M.-P., Dukas, R., Smith, R.W., Wang, J., Smolen, K. and McClelland, G.B. (2006) Lifetime performance in foraging honey bees: behaviour and physiology J. Exp. Biol. 209: 3828-3836.

Ayaz Hyder
Position: BSc Honours research (jointly with Jon Stone)

Modelling Ucrit in fish

Currently: PDF Yale U

Shawn Dipardo
Position: BSc Honours research

Exercise- and Cold-induced muscle remodelling in zebrafish

Currently: Dietician

McClelland, G.B., Craig, P.M., Dhekney, K and Dipardo, S. (2006) Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). J. Physiol. (London), 577(2):739-751.

Pam Leggatt
Position: BSc Honours research

CPTI gene expression in trout

Technicians
Charles Darwin

Fathima Ishna Iftikar (MSc McMaster U)
Position: Research Assistant

lipoprotein metabolism in dogfish


Currently PhD candidate Univ. of Auckland, NZ

   
   
 
Grant B. McClelland - McMaster University - Department of Biology - 1280 Main St. West Hamilton, ON L8S 4K1 Canada 
Office: 905.525.9140 x24266 - Lab: 905.525.9140 x23170 - Fax: 905.522.6066 | Grant can be e-mailed at grantm [at] mcmaster [dot] ca