Principle Investigator
Graham R. Scott

scottg2 [at] mcmaster [dot] ca (scottg2@mcmaster.ca)

Graham is an Assistant Professor and Canada Research Chair (Tier 2 in Comparative and Environmental Physiology) in the Department of Biology at McMaster University, and is a member of the McMaster Centre for Climate Change.

He attended McMaster University as an undergraduate student (1997-2002), where he began his research career during his thesis with Chris Wood. He completed an M.Sc. (2002-2004) with Trish Schulte and then a Ph.D. (2004-2009) with Bill Milsom at the University of British Columbia. He was a postdoctoral fellow with Ian Johnston at the University of St Andrews in Scotland (2010-2011) before returning to McMaster.

Graham is broadly interested in the comparative and evolutionary physiology of animals. He has a strong interest in integrating across levels of biological organization - from genome to organism - and his lab employs a diverse set of molecular, cellular, histological, physiological, and behavioural techniques. Research in the lab is complemented by field work to help understand how physiological systems work under real-world conditions.
Postdoctoral Fellows
Neal Dawson (Postdoctoral Fellow, 2014-present)

neal.dawson [at] gmail [dot] com (neal.dawson@gmail.com)

Neal joined the lab after doing a Ph.D. with Ken Storey at Carleton University. He is broadly interested in how animals survive low oxygen environments, particularly in how enzymatic changes in key metabolic pathways can facilitate life under these harsh conditions. His work in the Scott lab (in collaboration with Kevin McCracken at the University of Miami) is examining the mechanisms of high-altitude adaptation in highland ducks from the Andes, with a focus on how muscle and heart phenotypes are adjusted to cope with hypoxia and cold.
Graduate Students
Brittney Borowiec (Ph.D. program, 2013-present)

borowibg [at] mcmaster [dot] ca (borowibg@mcmaster.ca)

Brittney returned to the lab as a masters student after doing a B.Sc. thesis in the lab (2012-2013) on the effects of intermittent hypoxia on fish, and has since transferred to a PhD. Her PhD thesis is examining the mechanisms and evolution of the respiratory and metabolic responses of killifish to intermittent hypoxia.
Catherine Ivy (Ph.D. program, 2013-present)

ivycm [at] mcmaster [dot] ca (ivycm@mcmaster.ca)

Catie has a B.Sc. from the University of Guelph, where she did her thesis with Nick Bernier. After studying a variety of organisms throughout her undergrad, she became interested in comparative physiology and the unique adaptations of animals that live in extreme environments. Her thesis is examining respiratory adaptations to high-altitude in deer mice, with a focus on control of breathing in hypoxia.
Oliver Wearing (Ph.D. program, 2015-present)

wearingo [at] mcmaster [dot] ca (wearingo@mcmaster.ca)

Oliver joined the lab as a M.Sc. student after doing his undergrad degree at the University of Manchester, and has transferred to the Ph.D. program. He has a broad interest in comparative cardiovascular physiology, which began during his thesis with Holly Shiels and other previous work with Dane Crossley at the University of North Texas. His thesis is examining circulatory adaptations to high-altitude hypoxia in deer mice.
Undergraduate Students
Sarah Dyalsingh (B.Sc. program, 2016-present)

Sarah started in the lab as a volunteer and is now doing her B.Sc. thesis on a project to understand how high-altitude adaptation has altered lung structure and function in high-altitude deer mice.
Mary Greaves (B.Sc. program, 2017-present)

Mary is doing her B.Sc. thesis on a project to understand the developmental mechanisms underlying differences in breathing and the hypoxic ventilatory response between high-altitude and low-altitude deer mice.
Reem Hashem (B.Sc. program, 2017-present)

Reem's B.Sc. thesis is examining the physiological mechanisms underlying thermal adaptation in sunfish, to gain insight into the capacity of fish to adapt to climate change in the future.
Adhora Mir (B.Sc. program, 2017-present)

Adhora is examining how the evolution of haemoglobin genes impacts muscle phenotype in deer mice, to gain insight into the genetic basis of high-altitude adaptation.
Sarah Muir (B.Sc. program, 2016-present)

Sarah started in the lab as a volunteer and is now doing her B.Sc. thesis. Her project aims to understand how the evolution of the HIF-2a gene (Epas1) impacts muscle phenotype in deer mice, in order to gain insight into the genetic basis of high-altitude adaptation.
Former Lab Members
Nicole Pranckevicius
M.Sc. and B.Sc. theses
2014-2017

Cell physiology of the adrenal medulla in high-altitude deer mice

Current position:
Technician
McMaster University
Sherry Du
M.Sc. and B.Sc. theses
2012-2017

Effects of hypoxia and wastewater effluent on respiration and mitochondrial physiology in fish

Current position:
Research Technologist
Environment and Climate Change Canada
Canada Centre for Inland Waters
Sajeni Mahalingam
Ph.D. thesis
2013-2017

High-altitude adaptation and mitochondrial physiology in deer mice

Current position:
Instructional Assistant
McMaster University
Naman Shanishchara
B.Sc. thesis
2017

Effects of developmental hypoxia on muscle phenotype in high-altitude deer mice

Current position:
B.Sc. student
McMaster University
Emily Bellicoso
B.Sc. thesis and NSERC USRA summer student
2015-2017

Hypoxia signalling and high-altitude adaptation in deer mice

Current position:
Medical school
University of Toronto
Elizabeth Sangster
B.Sc. thesis
2016-2017

Development of breathing and the hypoxic ventilatory response in high-altitude deer mice

Current position:
TBD
Jasmine Choi
B.Sc. thesis and summer student
2015-2017

Effects of hypoxia and wastewater effluent on the respiratory physiology of bluegill sunfish

Current position:
Physiotherapy M.Sc. program
McMaster University
Kevin Tate
Postdoctoral Fellow
2014-2016

Cardiorespiratory mechanisms of thermogenic performance in high-altitude deer mice

Current position:
Assistant Professor
Truman State University
Sulayman Lyons
B.Sc. thesis
2015-2016

The physiology and histological phenotype of respiratory muscle (diaphragm) in high-altitude deer mice

Current position:
M.Sc. student
McMaster University
Gabriele Nandal
B.Sc. thesis and summer student
2015-2016

Flight muscle phenotype in Andean ducks from high altitudes

Current position:
M.Sc. student
University of Toronto
Fariborz Khajali
Visiting Professor
2014-2015

Mitochondrial physiology of bass and sunfish

Current position:
Professor
Shahrekord University, Iran
Maryam Vaseghi-Shanjani
B.Sc. summer student and volunteer
2015-2016

Effects of wastewater effluent on the respiratory physiology of bluegill sunfish and round goby

Current position:
M.Sc. student
McMaster University
Kevin Guo
B.Sc. thesis
2014-2015

Cardiac physiology and mitochondrial function in high-altitude deer mice

Current position:
Medical school
University of Ottawa
Eugene Choi
Technician
2014-2015

CO2/pH regulation during hypoxia in fish

Current position:
Doctor of Pharmacy program
University of Toronto
Kyle Crans
M.Sc. thesis
2012-2014

Mechanisms, evolution, and phenotypic plasticity of hypoxia tolerance among bass and sunfish (family Centrarchidae)

Current position:
Fisheries Biologist
Anishinabek/Ontario Fisheries Research Council
Julie-Anne Mendoza
B.Sc. volunteer
2014

Enzyme activities in air breathing and water breathing catfish from the Amazon

Current position:
Junior News Associate
Canada News Wire
Danielle Gillette
B.Sc. thesis
2013-2014

A comparison of muscle plasticity in response to intermittent and constant hypoxia in killifish

Current position:
Medical school
University College Cork
Ireland
Paras Patel
B.Sc. thesis and NSERC USRA summer student
2012-2014

High-altitude adaptation and the phenotype of skeletal and cardiac muscle in deer mice

Current position:
Law school
University of Toronto
Alex Young
B.Sc. thesis
2013-2014

The effects of temperature on hypoxia tolerance in bluegill and pumpkinseed sunfish

Current position:
Communications Officer
McMaster Students Union
Kim Darcy
B.Sc. thesis and lab volunteer
2011-2013

A comparison of the effects of intermittent and constant hypoxia on energy metabolism in killifish

Current position:
Nursing degree program
McMaster University
Todd Elogio
B.Sc. thesis
2012-2013

High-altitude adaptation and muscle phenotype in deer mice

Current position:
Medical school
Western University
Mikaela Lui
B.Sc. thesis and NSERC USRA summer student
2012-2013

High-altitude adaptation and oxygen transport capacity in deer mice

Current position:
Physiotherapy M.Sc. program
McMaster University

Meghan Schnurr
B.Sc. thesis and summer student
2011-2012

The effects of embryonic temperature on energy metabolism in zebrafish

Current position:
Environmental Scientist
Wek’eezhii Land and Water Board
Yellowknife, NWT

Yi (Kyle) Yin
B.Sc. thesis
2011-2012

The effects of temperature stress on embryonic development in zebrafish

Current position:
Technical Research Assistant
Clinical Genomics Centre
Mount Sinai Hospital
Active Collaborators
Nyamba Batbayar (University of Oklahoma)
Charles Bishop (Bangor University)
Pat Butler (University of Birmingham)
Zac Cheviron (University of Illinois at Urbana-Champaign)
Ben Evans (McMaster University)
Peter Frappell (University of Tasmania)
Todd Gillis (University of Guelph)
Lucy Hawkes (University of Exeter)
Grant McClelland (McMaster University)
Kevin McCracken (University of Miami)
Bill Milsom (University of British Columbia)
Jay Storz (University of Nebraska-Lincoln)
Pat Wright (University of Guelph)